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A Modular Methodology for the Synthesis of 4- and 3-Substituted Benzene and Aniline C-Ribonucleosides

✍ Scribed by Martin Štefko; Radek Pohl; Blanka Klepetářová; Michal Hocek


Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
390 KB
Volume
2008
Category
Article
ISSN
1434-193X

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Aniline (IV), specifically 13C labeled in the 4-or in the 3,5-position (IVa and IVb), has been synthesized with 55% yield from I3C labeled pnitrophenol (11). The reduction of the NO2 group and the removal of the OH group was performed in one step by reduction and hydrogenolytic cleavage o f p-nitrop