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A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease

✍ Scribed by Songhee Jeon; Shambhunath Bose; Jinyoung Hur; Kiyoung Jun; Young-Kyoon Kim; Kyoung Sang Cho; Byung-Soo Koo

Book ID: 116645443
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 783 KB
Volume: 137
Category: Article
ISSN: 0378-8741
DOI: 10.1016/j.jep.2011.06.046

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Background One of the pathological hallmarks of Alzheimer's disease (AD) is deposits of amyloid β-peptide (Aβ) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with Aβ reduces Aβ deposits and improves memory and learning deficits. Because recent clinical trials of immunizati