## Abstract Alterations in hippocampal cell proliferation have been identified in transgenic (tg) mouse models of Alzheimer's disease (AD); however, relatively little is known about the underlying mechanisms. Previously, we have demonstrated that endogenous level of BMP4 in the dentate gyrus (DG) a
✦ LIBER ✦
Limited expression of heparan sulphate proteoglycans associated with Aβ deposits in the APPswe/PS1dE9 mouse model for Alzheimer's disease
✍ Scribed by N. M. Timmer; M. K. Herbert; J. W. Kleinovink; A. J. Kiliaan; R. M. W. De Waal; M. M. Verbeek
- Book ID
- 110852710
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 616 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0305-1846
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Background One of the pathological hallmarks of Alzheimer's disease (AD) is deposits of amyloid β-peptide (Aβ) in neuritic plaques and cerebral vessels. Immunization of AD mouse models with Aβ reduces Aβ deposits and improves memory and learning deficits. Because recent clinical trials of immunizati