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A modified form of microtubule-associated tau protein is the main component of paired helical filaments

✍ Scribed by Amelia Nieto; Isabel Correas; Esteban Montejo de Garcini; Jesús Avila

Book ID: 115761083
Publisher: Elsevier Science
Year: 1988
Tongue: English
Weight: 949 KB
Volume: 154
Category: Article
ISSN: 0006-291X
DOI: 10.1016/0006-291x(88)90190-8

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Alzheimer's disease is characterized by the progressive deposition of two types of fibers in the affected brains, the amyloid fibers (consisting of the Abeta peptide, generating the amyloid plaques) and paired helical filaments (PHFs, made up of tau protein, forming the neurofibrillary tangles). Whi