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A modification of the APC resistance test and its application to the study of patients on coumarin therapy

✍ Scribed by Juan I Jorquera; Justo Aznar; M Angeles Fernández; JoséManuel Montoro; Rafael Curats; Pilar Casaña

Book ID
116087138
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
710 KB
Volume
82
Category
Article
ISSN
0049-3848

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A small-scale synthesis of high specific activity, N-(2-chloro-2-[3H]-ethyl)-N'-cyclohexyl-N-nitrosourea ([3H]-CCNU) has been accomplished from tritium-labelled ethanolamine. The product is pure by TLC and HPLC analysis and has been used successfully to modify DNA. The overall yield on radioactivity