Inhibition of Ξ±-synuclein aggregation by
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Ilona B. Bruinsma; Kim A. Bruggink; Karsten Kinast; Alexandra A. M. Versleijen;
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Article
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2011
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John Wiley and Sons
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English
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## Abstract The fibrillization of Ξ±βsynuclein (Ξ±βsyn) is a key event in the pathogenesis of Ξ±βsynucleinopathies. Mutant Ξ±βsyn (A53T, A30P, or E46K), each linked to familial Parkinson's disease, has altered aggregation properties, fibril morphologies, and fibrillization kinetics. Besides Ξ±βsyn, Lewy