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A Model for Small Heat Shock Protein Inhibition of Polyglutamine Aggregation

✍ Scribed by Healy, Eamonn F.; Little, Carley; King, Peter J.


Book ID
121404976
Publisher
Springer-Verlag
Year
2013
Tongue
English
Weight
540 KB
Volume
69
Category
Article
ISSN
1085-9195

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## Abstract The fibrillization of α‐synuclein (α‐syn) is a key event in the pathogenesis of α‐synucleinopathies. Mutant α‐syn (A53T, A30P, or E46K), each linked to familial Parkinson's disease, has altered aggregation properties, fibril morphologies, and fibrillization kinetics. Besides α‐syn, Lewy