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Small heat shock proteins differentially affect Aβ aggregation and toxicity

✍ Scribed by Sungmun Lee; Kenneth Carson; Allison Rice-Ficht; Theresa Good


Book ID
116293223
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
192 KB
Volume
347
Category
Article
ISSN
0006-291X

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## Abstract The fibrillization of α‐synuclein (α‐syn) is a key event in the pathogenesis of α‐synucleinopathies. Mutant α‐syn (A53T, A30P, or E46K), each linked to familial Parkinson's disease, has altered aggregation properties, fibril morphologies, and fibrillization kinetics. Besides α‐syn, Lewy