Genetic analysis of RET, GFRα1 and GDNF
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Laura Gil; Marta Azañedo; Marina Pollán; Eva Cristobal; Begoña Arribas; Luis Gar
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Article
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2002
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John Wiley and Sons
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French
⚖ 112 KB
👁 1 views
## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ proto‐oncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRα