Medullary thyroid carcinoma occurs sporadically or as a part of the inherited cancer syndrome multiple endocrine neoplasia (MEN) type 2. The MEN 2 gene has been identified as the RET proto-oncogene on chromosome 10. In MEN 2A, RET mutations are detectable in one of five cysteine codons within exons
โฆ LIBER โฆ
Genetic Screening for RET Mutations in Families with Multiple Endocrine Neoplasia 2 Syndromes
โ Scribed by M. ALEVIZAKI; H. SARIKA; D. A. KOUTRAS; A. SOUVATZOGLOU
- Book ID
- 111393396
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 555 KB
- Volume
- 816
- Category
- Article
- ISSN
- 0890-6564
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## Abstract Multiple endocrine neoplasia type 2A (MEN 2A) is associated with specific germline missense mutations in the __RET__ protoโoncogene. This locus encodes a receptor tyrosine kinase whose activation requires the formation of a multimeric receptor complex including GDNF as a ligand and GFRฮฑ