✦ LIBER ✦

A MODEL FOR CROSS-OVER TRIALS EVALUATING THERAPEUTIC PREFERENCES

✍ Scribed by J. K. LINDSEY; B. JONES

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 362 KB
Volume: 15
Category: Article
ISSN: 0277-6715
DOI: 10.1002/(sici)1097-0258(19960229)15:4<443::aid-sim161>3.0.co;2-i

No coin nor oath required. For personal study only.

✦ Synopsis

A preference trial is a special form of cross-over trial where clinical conditions determine when patients change treatment, in a prescribed order. This can be modelled using a geometric distribution. The model can be simply fitted using standard logistic regression methodology. The procedure is applied to a trial studying the effects of bronchodilators in the treatment of chronic asthma.

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