A Model Explaining the Correlations Between IL28B-Related Genotypes, Hepatitis C Virus Genotypes, and Viral RNA Levels
β Scribed by Magnus Lindh; Martin Lagging; Gunnar Norkrans; Kristoffer Hellstrand
- Book ID
- 119761707
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 328 KB
- Volume
- 139
- Category
- Article
- ISSN
- 0016-5085
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Hepatitis C virus (HCV) has many genotypes which are closely associated with the severity of chronic hepatitis and the response to antiviral therapy. Although HCV is essentially hepatotropic, several lines of evidence suggest that this virus can infect peripheral blood mononuclear cells (PBMC) in mo
## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNAβdependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire