A MLL-KIAA0284 fusion gene in a patient with secondary acute myeloid leukemia and t(11;14)(q23;q32)
β Scribed by Thomas Burmeister; Claus Meyer; Gundula Thiel; Richard Reinhardt; Eckhard Thiel; Rolf Marschalek
- Book ID
- 116304607
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 463 KB
- Volume
- 41
- Category
- Article
- ISSN
- 1079-9796
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The mixed lineage leukemia, __MLL__, gene is frequently rearranged in patients with secondary leukemia following treatment with DNA topoisomerase II inhibitors. By FISH and Southern blot analyses we identified a rearrangement in the __MLL__ gene due to a novel t(3;11)(q28;q23) chromosom
## Abstract We report a novel __MLL__βassociated chromosome translocation t(11;14)(q23;q24) in a child who showed signs of acute undifferentiated leukemia 3 years after intensive chemotherapy that included the topoisomeraseβII inhibitor VP 16. Screening of a cDNA library of the patient's leukemic c