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A MLH1 polymorphism that increases cancer risk is associated with better outcome in sporadic colorectal cancer

✍ Scribed by Nargisse Nejda; Daniel Iglesias; Mariano Moreno Azcoita; Vicente Medina Arana; Juan J. González-Aguilera; Antonia M. Fernández-Peralta

Book ID
113513561
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
142 KB
Volume
193
Category
Article
ISSN
0165-4608

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## Abstract Loss of DNA mismatch repair occurs in a variety of malignancies and is associated with genome‐wide instability of microsatellite repeats, a molecular phenotype referred to as microsatellite instability (MSI). MSI is a consistent feature of colorectal and endometrial tumors from patients