𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A missing link in the puzzle: Brown adipose tissue

✍ Scribed by Tugrul Purnak; Ersan Ozaslan; Cumali Efe; Hasan Sevimler

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
304 KB
Volume
51
Category
Article
ISSN
0270-9139

No coin nor oath required. For personal study only.

✦ Synopsis

After reading the article by Taura et al. with great interest, we really appreciate the ingenious work they have done. 1 In this study, they found type I collagen-producing cells do not originate from hepatocytes in a triple transgenic mouse model. Hepatocytes in vivo neither express mesenchymal markers nor exhibit a morphological change. All these results strongly challenge the earlier concept that hepatocytes in vivo acquire a mesenchymal phenotype through epithelial-mesenchymal transition (EMT) to produce the extracellular matrix (ECM), leading to liver fibrosis. Although they have provided solid evidence to show that EMT does not contribute to ECM in the process of liver fibrosis, several issues need to be further discussed.

The EMT phenomenon was first clearly demonstrated by Kaimori 2 and Zeisberg 3 simultaneously in mouse liver fibrosis. Although Taura et al. challenge the concept in vivo, the three groups independently showed that isolated primary hepatocytes exhibited fibroblast-like morphological change. Therefore, the different biological behaviors of hepatocytes in liver fibrosis between in vivo and in vitro models need to be reassessed. Studies on gene expression profiles of activated hepatic stellate cells revealed the

📜 SIMILAR VOLUMES

Hyperleptinaemia: the Missing Link in th
Hyperleptinaemia: the Missing Link in the Metabolic Syndrome?
✍ de Courten, M.; Zimmet, P.; Hodge, A.; Collins, V.; Nicolson, M.; Staten, M.; Do 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB 👁 1 views

Leptin's association with fasting insulin raises the possibility that hyperleptinaemia is an additional component of the Metabolic Syndrome, or perhaps underlies the syndrome. This population-based study of Western Samoans examined the relationship of serum leptin with insulin sensitivity assessed b

A procedure for the assay of norepinephr
A procedure for the assay of norepinephrine in adipose tissue
✍ R.L. Smith; R. Paoletti 📂 Article 📅 1962 🏛 Elsevier Science 🌐 English ⚖ 301 KB

Recent investigations in this laboratory have shown that norepinephrine (NE) is essential in ACTH-induced mobilization of free fatty acids (FFA) from adipose tissue (1). To carry out these studies it became necessary to determine the concentration of norepinephrine in the adipose tissue of normal an

A missing link in the transfer problem?
A missing link in the transfer problem? Examining how trainers learn about training transfer
✍ Holly M. Hutchins; Lisa A. Burke; Alice May Berthelsen 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB

## Abstract This study describes and reports the methods training professionals use to learn about training transfer. Specifically, this study focused on trainers' use and perceived utility of the literature (research and practitioner‐based) to develop their knowledge of how to support training tra

Adult Psychiatry—A Missing Link in the C
Adult Psychiatry—A Missing Link in the Child Protection Network: A Response to Reder and Duncan
✍ Dr. Adrian Falkov 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB 👁 1 views

The child protection network would be enhanced through more active participation by adult psychiatric services. This is Reder and Duncan's (Child Abuse Review, Vol. 6(1): 000±000) key theme in commenting on the study of Part 8 Reviews (Falkov, 1996). Also important, however, must be the routine cons

The Use of Person–Group Fit for Employme
The Use of Person–Group Fit for Employment Selection: A Missing Link in Person–Environment Fit
✍ James D. Werbel; Danny J. Johnson 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 146 KB 👁 1 views

## Abstract Given an increased emphasis on work teams in organizations, it is important to select applicants based on their ability to make contributions to a given work team. This paper proposes that person–group fit should be useful to select applicants for work teams and suggests that effective