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A misquoted mutation in exon16 of the BRCA2 gene

โœ Scribed by Agapi Kataki; Anastasia Derventzi; Ilias Gomatos; Manoussos M. Konstadoulakis

Book ID
106251982
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
258 KB
Volume
51
Category
Article
ISSN
1435-232X

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## Abstract Hereditary breast cancer constitutes 5โ€“10% of all breast cancer cases. Inherited mutations in the BRCA1 and BRCA2 tumor-suppressor genes account for the majority of hereditary breast cancer cases. The BRCA1 C-terminal region (BRCT) has a functional duplicated globular domain, which help