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The Exon 13 Duplication in the BRCA1 Gene Is a Founder Mutation Present in Geographically Diverse Populations

โœ Scribed by S. Mazoyer

Book ID
117853345
Publisher
American Society of Human Genetics
Year
2000
Tongue
English
Weight
128 KB
Volume
67
Category
Article
ISSN
0002-9297

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## Abstract Hereditary breast cancer constitutes 5โ€“10% of all breast cancer cases. Inherited mutations in the BRCA1 and BRCA2 tumor-suppressor genes account for the majority of hereditary breast cancer cases. The BRCA1 C-terminal region (BRCT) has a functional duplicated globular domain, which help