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A Misclassification Model for the Non-Disjunction Fraction in Meiosis I

✍ Scribed by Rosangela H. Loschi; João V. D. Monteiro; Cristiane S. Souto

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
159 KB
Volume
50
Category
Article
ISSN
0323-3847

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✦ Synopsis

Abstract

In this paper we introduce a misclassification model for the meiosis I non‐disjunction fraction in numerical chromosomal anomalies named trisomies. We obtain posteriors, and their moments, for the probability that a non‐disjunction occurs in the first division of meiosis and for the misclassification errors. We also extend previous works by providing the exact posterior, and its moments, for the probability that a non‐disjunction occurs in the first division of meiosis assuming the model proposed in the literature which does not consider that data are subject to misclassification. We perform Monte Carlo studies in order to compare Bayes estimates obtained by using both models. An application to Down Syndrome data is also presented. (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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