A mild titanium-based system for the reduction of amides to aldehydes

✍ Scribed by Stéphane Laval; Wissam Dayoub; Alain Favre-Reguillon; Patrice Demonchaux; Gérard Mignani; Marc Lemaire

• Publisher: Elsevier Science
• Year: 2010
• Tongue: French
• Weight: 366 KB
• Volume: 51
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2010.02.008

✦ Synopsis

A mild method for the reduction of amides to aldehydes using 1,1,3,3-tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The reaction occurs under mild conditions and allows the reduction of aromatic as well as aliphatic, tertiary amides to the corresponding aldehydes, in good yields. This methodology was extended to the reduction of aromatic secondary and primary amides to the corresponding aldehydes.