A mild palladium(II) catalyzed desilylation of phenolic t-butyldimethylsilyl ethers
β Scribed by Noel S Wilson; Brian A Keay
- Book ID
- 103401999
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 189 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A variety of phenolic silyl ethers are easily desilylated in good to excellent yields by treatment with 1.1 equivalents of K2CO3, and ethanol containing 5 equivalents of water.
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A mild and efficient method for the deprotection of aryl t-butyldimethysilyl (TBS) ethers is described. The protecting group TBS could be cleaved from aryl silyl ethers using cesium carbonate in DMF-H 2 O at room temperature to give the corresponding phenols in excellent yields. The reaction conditi