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A mild, efficient and selective deprotection of t-butyldimethylsilyl-protected phenols using cesium carbonate

✍ Scribed by Zhi-Yong Jiang; Yan-Guang Wang

Book ID: 104253518
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 143 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00736-6

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✦ Synopsis

A mild and efficient method for the deprotection of aryl t-butyldimethysilyl (TBS) ethers is described. The protecting group TBS could be cleaved from aryl silyl ethers using cesium carbonate in DMF-H 2 O at room temperature to give the corresponding phenols in excellent yields. The reaction conditions allowed selective deprotection of aryl TBS-protected phenols in the presence of TBS, phenyloxycarbonyl or tetrahydropyranyl-protected alcohols.

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