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A Microreactor with Thousands of Subcompartments: Enzyme-Loaded Liposomes within Polymer Capsules

✍ Scribed by Brigitte Städler; Rona Chandrawati; Andrew D. Price; Siow-Feng Chong; Kerry Breheney; Almar Postma; Luke A. Connal; Alexander N. Zelikin; Frank Caruso

Book ID: 102728237
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 569 KB
Volume: 48
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200900386

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✦ Synopsis

Abstract

Fully loaded: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol‐modified polymers allows the preparation of capsosomes—liposome‐compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction confirmed the presence of active cargo within the capsosomes and was used to determine the number of subcompartments within this novel biomedical carrier system.magnified image

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