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A Microreactor with Thousands of Subcompartments: Enzyme-Loaded Liposomes within Polymer Capsules

✍ Scribed by Brigitte Städler; Rona Chandrawati; Andrew D. Price; Siow-Feng Chong; Kerry Breheney; Almar Postma; Luke A. Connal; Alexander N. Zelikin; Frank Caruso

Book ID
102725145
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
569 KB
Volume
121
Category
Article
ISSN
0044-8249

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A Microreactor with Thousands of Subcomp
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## Abstract **Fully loaded**: Noncovalent anchoring of liposomes into polymer multilayered films with cholesterol‐modified polymers allows the preparation of capsosomes—liposome‐compartmentalized polymer capsules (see picture). A quantitative enzymatic reaction confirmed the presence of active carg

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Polymer capsules containing multiple liposomes, termed capsosomes, are a promising new concept toward the design of artificial cells. Herein, we report on the fundamental aspects underpinning the assembly of capsosomes. A stable and high loading of intact liposomal cargo into a polymer film was achi