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A methodology to establish a database to study gene environment interactions for childhood asthma

โœ Scribed by Stephen W Turner; Jon G Ayres; Tatiana V Macfarlane; Anil Mehta; Gita Mehta; Colin N Palmer; Steve Cunningham; Tim Adams; Krishnan Aniruddhan; Claire Bell; Donna Corrigan; Jason Cunningham; Andrew Duncan; Gerard Hunt; Richard Leece; Una MacFadyen; Jonathan McCormick; Sally McLeish; Andrew Mitra; Deborah Miller; Elizabeth Waxman; Alan Webb; Slawomir Wojcik; Somnath Mukhopadhyay; Donald Macgregor


Book ID
115008500
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
407 KB
Volume
10
Category
Article
ISSN
1471-2288

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โœ Wei Q. Deng; Guillaume Parรฉ ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 519 KB

Detection of gene-environment interactions using an exhaustive search necessarily raises the multiple hypothesis problem. While frequently used to control for experiment-wise type I error, Bonferroni correction is overly conservative and results in reduced statistical power. We have previously shown