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A method to measure dual NK1/NK2-antagonist activity in dogs

✍ Scribed by Joseph E Sherwood; Simon Young; William Selig; Aileen Schilling; William Kreutner; Robert W Egan; Richard W Chapman

Book ID: 114343282
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 70 KB
Volume: 39
Category: Article
ISSN: 1056-8719
DOI: 10.1016/s1056-8719(98)00003-3

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high