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A method for the synthesis of ribonucleoside and deoxyribonucleoside-5′-triphosphates

✍ Scribed by E.S. Canellakis; M.E. Gottesman; H.O. Kammen


Book ID
115788767
Publisher
Elsevier Science
Year
1960
Weight
385 KB
Volume
39
Category
Article
ISSN
0006-3002

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A new class of nucleotides, with one of the two non-bridging oxygens at or-phosphorus replaced by a borane (BH3) group, has shown potential applications in DNA sequencing. We have developed a convenient method for the synthesis of the 2'-deoxy-5'-(ot-P-borano)triphosphates of adenosine, guanosine, c