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A method for the synthesis of isomerically pure saturated mixed-chain phosphatidylcholines

✍ Scribed by Jeffrey T. Mason; Anthony V. Broccoli; Ching-Hsien Huang

Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
478 KB
Volume
113
Category
Article
ISSN
0003-2697

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✦ Synopsis

A method is described for the partial synthesis of saturated mixed-chain phosphatidylcholines of a high degree (typically 99 mol%) of purity. This procedure has been designed to eliminate the contamination of the mixed-chain product by symmetric chain phosphatidylcholine and the mixed-chain isomer of the desired product, the two principal impurities introduced by previous techniques. This high degree of purity is obtained by employing a method designed for the complete enzymatic hydrolysis of the C-2 fatty acyl moiety in saturated symmetric phosphatidylcholines and a new technique for the acylation of lysophosphatidylcholines employing the catalyst 4-pyrrolidinopyridine.

The versatility of this new procedure is illustrated with the synthesis of several saturated mixed-chain phosphatidylcholines.

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