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A method for the preparation of [13C6]-labelled 2-substituted naphthalenes

✍ Scribed by George J. Ellames; John M. Herbert

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
91 KB
Volume
53
Category
Article
ISSN
0022-2135

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✦ Synopsis

A reliable route is described for the preparation of various 2-substituted derivatives of [1,2,3,4,4a,8a-13 C 6 ]-naphthalene via the bromide 10. The approach is used to prepare [naphthalene-1,2,3,4,4a,8a-13 C 6 ]-2-(2-bromoethyl)naphthalene (1), a key intermediate in the synthesis of labelled SR57746A, Xaliproden (2).

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