1998 amide formation, amide hydrolysis amide formation, amide hydrolysis O 0320 23 -069 A New Mild Method for the Cleavage of the Amide Bond: Conversion of Secondary and Tertiary Amides to Esters. -A variety of secondary and tertiary amides (I) (21 examples) is efficiently converted to the correspon
A method for introducing secondary amide bonds into strained cyclic peptides
β Scribed by Daniel H. Rich; J.P. Tam
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- French
- Weight
- 113 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0040-4039
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## Abstract We present here a new method using methoxyphenylacetic acid (MPA) as the chiral derivatizing agent (CDA) for the assignment of absolute configuration of cyclic secondary amines. The MPA amides were prepared using the purificationβfree βmix and shakeβ method. A detailed conformational an
The cyclic hexapeptide cycle[ -Pro'-Gly2-Glu3 (OBzl) -Pro4-Phe5-Leu6-] ( 1 ; OBzl: benzyl ester) was modeled and synthesized to be used as a chiral site for the separation of enantiomers. Total correlation spectroscopy and nuclear Ovehauser effect spectroscopy spectra of the peptide in CDCIB showed