A method for determining the pharmacokinetics of endogenous creatinine without exogenous creatinine administration

✍ Scribed by M. S. S. Chow

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 330 KB
• Volume: 6
• Category: Article
• ISSN: 0142-2782
• DOI: 10.1002/bdd.2510060210

✦ Synopsis

A method for determining the individual pharmacokinetics of endogenous creatinine is derived and applied in 10 post-renal transplant patients. All patients had rapidly decreasing serum creatinine concentrations (C), but relatively constant creatinine clearance (CI,,) during the study period. Based on the multiple consecutive CI,, and the corresponding C , the elimination rate constant (K), volume of distribution (V), and daily creatinine production rate (R) for each patient were derived. The creatinine 'normal' tIl2 (corresponding to a CI,, of 120 ml min-I) was also calculated. In the 10 patients studied, the observed CI,, ranged from 29.5 to 72.7 ml min-I. The corresponding calculated mean K was 0.076 f 0.028 h-I; R was 20.0 f 5.7 mg kg-' day-', and V was 0-60 f 0.1 I kg-I. The 'normal' tlI2 was 4.0 k 0.93 h. These