𝔖 Bobbio Scriptorium
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A method for assaying hepatic morphine UDP-glucuronyl transferase

✍ Scribed by Richard D. Strickland; Daniel H. Gregory; Joan L. Lynch


Book ID
115766350
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
478 KB
Volume
11
Category
Article
ISSN
0006-2944

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The infusion of a closely related derivative of bilirubin, its dimethyl diester (DME), into jaundiced (jj) Gunn rats was associated with biliary excretion of mono-and diglucuronides of bilirubin. In uitro incubation of DME with liver microsomes from jj rats demonstrated sequential demethylation and