A rat liver microsomal carboxyesterase and a bilirubin UDP-glucuronyl transferase are responsible for the formation of bilirubin glucuronides from bilirubin dimethyl ester

The presence of a microsomal UDP-glucuro

The presence of a microsomal UDP-glucuronyl transferase for bilirubin in homozygous jaundiced gunn rats and in the crigler-najjar syndrome

✍ Gerard B. Odell; Julio O. Cukier; Glenn R. Gourley 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 962 KB

The infusion of a closely related derivative of bilirubin, its dimethyl diester (DME), into jaundiced (jj) Gunn rats was associated with biliary excretion of mono-and diglucuronides of bilirubin. In uitro incubation of DME with liver microsomes from jj rats demonstrated sequential demethylation and