A Metal-Free Transfer Hydrogenation: Organocatalytic Conjugate Reduction of α,β-Unsaturated Aldehydes
✍ Scribed by Jung Woon Yang; Maria T. Hechavarria Fonseca; Benjamin List
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 162 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0044-8249
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📜 SIMILAR VOLUMES
## Abstract The first example of an organocatalytic asymmetric Michael addition of aldehydes to α,β‐unsaturated thiol esters promoted by chiral diphenylprolinol silyl ether is presented. The reaction occurs with good yields, diastereoselectivity and excellent enantioselectivity.
Organocatalysis [1] has expanded widely within the last few years, since the rediscovery of the proline-catalyzed aldol reaction. [2] Since then, several different methods, such as fluorination, [3] chlorination, [4] bromination, [5] sulfenylation, [6] amination, [7] and Mannich reactions, [8] have