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A Mechanism of Cyclin D1 Action Encoded in the Patterns of Gene Expression in Human Cancer

โœ Scribed by Justin Lamb; Sridhar Ramaswamy; Heide L. Ford; Bernardo Contreras; Robert V. Martinez; Frances S. Kittrell; Cynthia A. Zahnow; Nick Patterson; Todd R. Golub; Mark E. Ewen

Book ID
117269608
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
674 KB
Volume
114
Category
Article
ISSN
0092-8674

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The cyclin D1/CCND1 oncogene (PRAD1) is amplified in 15% of primary human breast cancers and overexpressed in 30-50% of breast cancers, suggesting that mechanisms in addition to DNA amplification may lead to deregulated expression of this gene in breast cancer. Cyclin D1 overexpression at a higher f