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A mechanism of catalyzed GTP hydrolysis by Ras protein through magnesium ion

✍ Scribed by Qiang Lu; Nicolas Nassar; Jin Wang


Book ID
113555192
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
975 KB
Volume
516
Category
Article
ISSN
0009-2614

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Quantum chemical modeling of the GTP hyd
✍ Igor A Topol; Raul E Cachau; Alexander V Nemukhin; Bella L Grigorenko; Stanley K πŸ“‚ Article πŸ“… 2004 πŸ› Elsevier Science 🌐 English βš– 712 KB

We present results of the modeling for the hydrolysis reaction of guanosine triphosphate (GTP) in the RAS -GAP protein complex using essentially ab initio quantum chemistry methods. One of the approaches considers a supermolecular cluster composed of 150 atoms at a consistent quantum level. Another