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Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

✍ Scribed by Schweins, Thomas; Geyer, Matthias; Scheffzek, Klaus; Warshel, Arieh; Kalbitzer, Hans Robert; Wittinghofer, Alfred

Book ID: 109964462
Publisher: Nature Publishing Group
Year: 1995
Tongue: English
Weight: 830 KB
Volume: 2
Category: Article
ISSN: 1072-8368
DOI: 10.1038/nsb0195-36

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The functions of G proteins--like those of bacterial elongation factor (EF) Tu and the 21 kDa ras proteins (p21ras)--depend upon their abilities to bind and hydrolyze GTP and to assume different conformations in GTP- and GDP-bound states. Similarities in function and amino acid sequence indicate tha