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A mechanism for P-glycoprotein action in multidrug resistance: are we there yet?

✍ Scribed by Stephan Ruetz; Philippe Gros

Book ID
116103737
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
482 KB
Volume
15
Category
Article
ISSN
0165-6147

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For years, P-glycoprotein (P-gp) has been purported to be a membrane transporter capable of selectively transporting many (but not all) lipophilic anticancer drugs with diverse chemical structures. Because the alleged functions of P-gp provide a straightforward, near-perfect explanation for the mole