This study presents matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) as a powerful tool to analyze and characterize oligonucleotides covalently linked to a solid support during their synthesis. The analysis of the fragment ions generated either in negative o
A matrix of 3,4-diaminobenzophenone for the analysis of oligonucleotides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
โ Scribed by Fu, Y.
- Book ID
- 118184486
- Publisher
- Oxford University Press
- Year
- 2006
- Tongue
- English
- Weight
- 390 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0305-1048
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Cation adduction to oligonucleotides and nucleic acids during mass spectrometric analysis is a recurrent problem. We have found that the use of organic base solutions of high gas-phase proton affinity, as used previously in electrospray ionization mass spectrometry, can significantly reduce the cati
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