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A mast cell degranulation screening assay for the identification of novel mast cell activating agents

✍ Scribed by Staats, Herman F.; Kirwan, Shaun M.; Choi, Hae Woong; Shelburne, Christopher P.; Abraham, Soman N.; Leung, Gulice Y. C.; Chen, David Y.-K.

Book ID
111909908
Publisher
The Royal Society of Chemistry
Year
2013
Tongue
English
Weight
403 KB
Volume
4
Category
Article
ISSN
2040-2503

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Background: Mast cells are primary mediators of allergic inflammation. Antigen-mediated crosslinking of their cell surface immunoglobulin E (IgE) receptors results in degranulation and the release of proinflammatory mediators including histamine, tumor necrosis factor-␣, and leukotrienes. Methods: M