✦ LIBER ✦

A low rate of hepatitis B virus vaccine breakthrough infections in Mongolia

✍ Scribed by Samreen Ijaz; Janchiv Khulan; Sara L. Bissett; R. Bridget Ferns; Pagbajabyn Nymadawa; Richard S. Tedder

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 142 KB
Volume: 78
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.20738

No coin nor oath required. For personal study only.

✦ Synopsis

A nation-wide hepatitis B virus (HBV) immunization program of all newborn babies was launched in Mongolia in 1991. However, the continuation of clinical icteric viral hepatitis infections in children led to the investigation to determine whether HBV breakthrough infections were occurring and if any were due to hepatitis B surface antigen (HBsAg) mutants. Hepatitis A virus (HAV) infections accounted for most of these cases with 3% of the jaundiced children shown to have acute hepatitis B. Hepatitis B vaccine protection was 93% against HBV infection and 97% against HBV carriage. A G145A ''escape mutant'' was found in one HBV carrier child only. Anti-HBs levels, however, were low with 85% having titers less than 100 IU/L, 46% of whom had levels less than 10 IU/L. The results from this study demonstrate that the HBV immunization program in Mongolia provides an effective level of protection. However, continued surveillance of breakthrough infections and close monitoring of ''vaccine escape'' mutants is required.

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