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A longitudinal analysis of cytotoxic T lymphocyte precursor frequencies to the hepatitis B virus in chronically infected patients

✍ Scribed by G. K. Sing; A. Ladhams; S. Arnold; H. Parmar; X. Chen; J. Cooper; L. Butterworth; K. Stuart; D. D’Arcy; W. G. E. Cooksley

Book ID
108885652
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
990 KB
Volume
8
Category
Article
ISSN
1352-0504

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Relationship Between Expression of Hepatitis B Virus Antigens in Isolated Hepatocytes and Autologous Lymphocyte Cytotoxicity in Patients with Chronic Hepatitis B Virus Infection
✍ Nikolai V. Naumov; Mario Mondelli; Graeme J. M. Alexander; Richard S. Tedder; Ad 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 721 KB

Previous studies demonstrated that peripheral blood lymphocytes are cytotoxic to autologous hepatocytes in patients with chronic hepatitis B virus infection. We examined whether cytotoxicity is specifically directed against hepatocytes expressing HBsAg or HBcAg. Viral antigens were detected by immun