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A liquid chromatography–tandem mass spectrometry method for the determination of nodularin-R in human plasma and its preliminary clinical application

✍ Scribed by Ying Yu; Jinhui Xu; Yuan Liu; Shanlei Qiao; Yun Chen

Book ID: 116349463
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 374 KB
Volume: 413
Category: Article
ISSN: 0009-8981
DOI: 10.1016/j.cca.2012.01.039

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquid–liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to