The analysis of 650 HLA-A:HAL-B:Bf three-factor haplotypes revealed significant associations only between alleles of the very closely linked genes HLA-A and HLA-B, and Bf, respectively. Most striking is the highly significnat association of the rare Bf variant F1 with HLA-B18 and of S1 with HLA-B13,
A linkage study of HLA and inherited adenocarcinoma of the colon
β Scribed by Dr. Michael V. Sivak Jr; Donna Schleutermann Sivak; William A. Braun; B. H. Sullivan Jr
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 493 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0008-543X
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Bf allele frequencies in a material of 172 unrelated Norwegians are given. Bf/HLA linkage relations in 49 informative matings with 178 children, and Bf/HLA association data of a material of 212 Bf-HLA haplotypes are presented. Of 171 informative meioses, there were no Bf-HLA-B recombinations, while