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TheBflocus in the HLA region of chromosome 6: Linkage and association studies

✍ Scribed by B. Olaisen; P. Teisberg; T. Gedde-Dahl; E. Thorsby

Publisher
Springer
Year
1975
Tongue
English
Weight
302 KB
Volume
30
Category
Article
ISSN
0340-6717

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✦ Synopsis

Bf allele frequencies in a material of 172 unrelated Norwegians are given. Bf/HLA linkage relations in 49 informative matings with 178 children, and Bf/HLA association data of a material of 212 Bf-HLA haplotypes are presented. Of 171 informative meioses, there were no Bf-HLA-B recombinations, while 3 out of 158 Bf-HLA-A informative meioses showed recombination. There is significant association between the BfF and the HLA-BW35 allele. It is concluded that the Bf locus is situated on the HLA-B side of HLA-A within the HLA region, in very close proximity to HLA-B.

πŸ“œ SIMILAR VOLUMES

Lack of linkage between gene(s) controll
Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man
✍ Ch. Rittner; W. Opferkuch; B. Wellek; H. Grosse-Wilde; P. Wernet πŸ“‚ Article πŸ“… 1976 πŸ› Springer 🌐 English βš– 337 KB

The family of an individual was studied who lacks the seventh component of complement in his serum (C7 homozygous deficiency). Both parents are C7 heterozygous-deficient. In this investigation, the following parameters were determined: complement components in functional and immunochemical tests; HL