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A link between p73 transcriptional activity and p73 degradation

✍ Scribed by Wu, Liqing; Zhu, Hongyan; Nie, Linghu; Maki, Carl G


Book ID
110068613
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
222 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract The tumor suppressor p53‐related p73 shares significant amino‐acid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNA‐binding sites and activates p53‐responsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their