SIRT1 interacts with p73 and suppresses
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Jin Ming Dai; Zhi Yan Wang; Dao Chun Sun; Ru Xian Lin; Sheng Qi Wang
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Article
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2006
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John Wiley and Sons
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English
β 243 KB
## Abstract The tumor suppressor p53βrelated p73 shares significant aminoβacid sequence identity with p53. Like p53, p73 recognizes canonical p53 DNAβbinding sites and activates p53βresponsive target genes and induces apoptosis. Moreover, SIRT1 binds to p53 while repressing the expression of their