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A Link between Cholesterol Levels and Phenobarbital Induction of Cytochromes P450

โœ Scribed by Jean-Claude Ourlin; Christoph Handschin; Michel Kaufmann; Urs A. Meyer


Book ID
115589514
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
194 KB
Volume
291
Category
Article
ISSN
0006-291X

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A soluble, cytochrome P-450-dependent fatty acid hydroxylase--epoxidase complex from Bacillus megaterium ATCC 14581 can be induced more than 100-fold by the addition of phenobarbital or one of its analogs (hexobarbital) to the growth medium. These barbiturate inducers are apparently not substrates f