A LHASA analysis of taxol

✍ Scribed by Erik L. M. van Rozendaal; Martin A. Ott; Hans W. Scheeren

• Publisher: Elsevier Science
• Year: 2010
• Tongue: English
• Weight: 588 KB
• Volume: 113
• Category: Article
• ISSN: 0165-0513
• DOI: 10.1002/recl.19941130507

✦ Synopsis

Abstract

A retrosynthetic analysis using the computer program LHASA of the promising antitumor agent taxol (1) is described, which resulted in a synthetic route with the following key steps: an intramolecular Diels‐Alder reaction generating the AB rings, and the coupling reactions of the required diene and dienophile with a CD‐ring fragment. The feasibility of the route is studied by comparing the LHASA analysis with related chemistry from the literature. Finally, a critical discussion about the usability of the LHASA program for the planning of complex organic molecules is given.]