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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

✍ Scribed by Berns, Katrien; Hijmans, E. Marielle; Mullenders, Jasper; Brummelkamp, Thijn R.; Velds, Arno; Heimerikx, Mike; Kerkhoven, Ron M.; Madiredjo, Mandy; Nijkamp, Wouter; Weigelt, Britta

Book ID
109892744
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
656 KB
Volume
428
Category
Article
ISSN
0028-0836

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## Abstract A p53 C‐terminal peptide (aa 361–382, p53p), fused at its C‐terminus to the minimal carrier peptide of __antennapedia__ (17 aa, Ant; p53p‐Ant), induced rapid apoptosis in human cancer cells, __via__ activation of the Fas pathway. We examined p53p‐Ant mechanism of action, toxicity in var