𝔖 Bobbio Scriptorium
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A kit for the production and fast isolation of medically useful fluorine-18

✍ Scribed by K.L. Scholz; V.J. Sodd


Publisher
Elsevier Science
Year
1972
Weight
306 KB
Volume
23
Category
Article
ISSN
0020-708X

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## Abstract Fluoroquinolones are an important class of antibiotic agents with a broad spectrum of antibacterial activity. Labelling of fluoroquinolones with fluorine‐18 is of interest for the performance of pharmacokinetic measurements and the visualization of bacterial infections in humans with po

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## Abstract FPyKYNE (2‐fluoro‐3‐pent‐4‐yn‐1‐yloxypyridine) is a novel fluoropyridine‐based structure, designed for the fluorine‐18 labelling of macromolecules using copper‐catalysed Huisgen 1,3‐dipolar cycloaddition (click chemistry). FPyKYNE (non‐labelled as reference), as well as the 2‐bromo, 2‐n