✦ LIBER ✦

A-kinase anchoring proteins: From protein complexes to physiology and disease

✍ Scribed by Graeme K. Carnegie; Christopher K. Means; John D. Scott

Book ID: 102280739
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 315 KB
Volume: 61
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.168

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✦ Synopsis

Abstract

Protein scaffold complexes are a key mechanism by which a common signaling pathway can serve many different functions. Sequestering a signaling enzyme to a specific subcellular environment not only ensures that the enzyme is near its relevant targets, but also segregates this activity to prevent indiscriminate phosphorylation of other substrates. One family of diverse, well‐studied scaffolding proteins are the A‐kinase anchoring proteins (AKAPs). These anchoring proteins form multi‐protein complexes that integrate cAMP signaling with other pathways and signaling events. In this review, we focus on recent advances in the elucidation of AKAP function. © 2009 IUBMB IUBMB Life, 61(4): 394–406, 2009

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